Prof.Masahito Hosokawa

Issuing time:2021-09-17 13:05

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Masahito Hosokawa


Associate Professor


Waseda University


100-word biography:

Masahito   Hosokawa obtained his Ph.D degree at Tokyo University of Agriculture and Technology   in 2010. After a postdoctoral training at Shizuoka cancer center between 2011   and 2013, he joined Prof. Haruko Takeyama laboratory at Waseda University in   2013 (as an associate professor from 2021) and started single-cell research   as a JST-PRESTO researcher in 2015 to 2018. He found bitBiome, Inc. based on   the developed single-cell technology in 2018. His research is   interested in developing and applying novel microfluidic tools for   single-cell genomics and transcriptomics.


Development of   technologies for single-cell genome sequencing of uncultured microbes


A wide variety of microbes   exist in various natural environments, including the ocean, soil, and our   bodies. However, most of them are uncultured microbes that have not been   isolated and cultured, and there are many challenges to understanding their   characteristics. We have developed a single-cell genome sequencing technology   as a powerful tool to study these uncultured microorganisms. Single-cell   genome analysis enables us to obtain genomic information from diverse   microbial populations individually, which is difficult to conduct with   conventional metagenome analysis. It can be used for various studies, such as   metabolic analysis, screening for functional genes, and identification of   useful chemical synthesis pathways. In addition, by comparing the acquired   genomes within the same species, it is possible to perform a detailed   comparative analysis at the strain level and even functional gene pathways.   By taking advantage of these features, it is possible to describe the   functions of microorganisms one by one. We are now attempting to create a   genomic catalog of each microorganism using this technology in the study of   the intestinal and environmental microbiome.