Dr. Han graduated from the Suzhou Medical College and went to the US to obtain his Ph.D. in Medical Genetics from the University of Alabama and Birmingham. He became lab director and assistant professor at UAB before his entrepreneur ventures. He invented several multiplex PCR technologies and used them to start a number of biotech companies, including Genaco, Diatherix, iCubate, and iRepertoire.
In 2009, we first reported and patented methods to profile immune repertoire. Now, with quantitative and sensitive dam-PCR technology, we can sequence all 7 chains of T and B cell receptors in one reaction to obtain the “Adaptome” information. The presentation will discuss applications in immune oncology, monoclonal antibody development via single cell sequencing, cell therapy, vaccine evaluation, MRD, and disease specific diagnostics, including COVID-19.