100-word biography: | Lingqian Chang is a full professor at the School of Biological Science and Medical Engineering, and Co-director of Institute of Single Cell Engineering, Beihang University. Before joined Beihang, he was a tenure-track assistant professor of Biomedical Engineering at University of North Texas (UNT), USA. He obtained his Ph.D. degree of Biomedical Engineering from Ohio State University (OSU). His research interests are in the fields of nanotechnology for single-cell gene transfection and cell micro-manipulation, with specific focus on intracellular gene analysis and treatment. In these fields he has co-authored over 60 publications on peer-reviewed journals, such as Nature Nanotechnology, Nano Letters, Small. He received “1000 Youth Talents Plan” (2017); OSU Presidential Fellowship (2015); NSF Fellowship (2012 – 2014), OSU University Fellowship (2011) among other academic awards. |
Abstract: | Advanced Bio-Chip is wide applicable to single cell, now has been recognized as one of the cutting-edge research themes in life science, ranging from in vitro cell biology toward in vivo medicine. We currently attempt to innovate or renovate micro or nano- biochip by integrating nano-biotechnology, microfluidics, and microelectronics. One core technique in our group, known as nano-electroporation (NEP), allows for high-throughput, and precisely delivery of gene / drugs into living cells at single-cell resolution. We developed on-chip cell manipulation techniques to make the NEP platform more controllable and efficient. The in vitro applications of the NEP platform have been demonstrated in various studies, such as single living cell analysis, disease modeling, live cell sampling, EVs for gene therapy, most oriented to cancer diagnosis and therapy. Our recent efforts to in vivo application have achieved skin-patchable, fully implantable NEP devices for on-body, in-body gene therapy, would healing and in vivo modeling. |
