Prof.Lingqian Chang

Issuing time:2021-09-17 11:06



Lingqian Chang




School of Biological Science and Medical   Engineering, Beihang University


100-word biography:

Lingqian Chang is a full professor at the School of Biological   Science and Medical Engineering, and Co-director of Institute   of Single Cell Engineering, Beihang University. Before joined Beihang, he   was a   tenure-track assistant professor of Biomedical Engineering at University of   North Texas (UNT), USA. He obtained his Ph.D. degree of Biomedical   Engineering from Ohio State University (OSU). His research interests are in   the fields of nanotechnology for single-cell gene transfection and cell   micro-manipulation, with specific focus on intracellular gene analysis and   treatment.   In these fields he has co-authored over 60 publications on peer-reviewed   journals, such as Nature Nanotechnology, Nano Letters, Small.   He received   “1000 Youth Talents Plan” (2017); OSU Presidential Fellowship (2015); NSF   Fellowship (2012 – 2014), OSU University Fellowship (2011) among other   academic awards.


Single Cell Micro-/Nano-Chip


Advanced Bio-Chip is wide applicable to single   cell, now has been recognized as one of the cutting-edge research themes in   life science, ranging from in vitro cell biology toward in vivo   medicine.

We currently attempt to innovate or   renovate micro or nano- biochip by integrating nano-biotechnology,   microfluidics, and microelectronics. One core technique in our group, known   as nano-electroporation (NEP), allows for high-throughput, and precisely   delivery of gene / drugs into living cells at single-cell resolution. We   developed on-chip cell manipulation techniques to make the NEP platform more   controllable and efficient. The in vitro applications of the NEP   platform have been demonstrated in various studies, such as single living   cell analysis, disease modeling, live cell sampling, EVs for gene therapy,   most oriented to cancer diagnosis and therapy. Our recent efforts to in vivo   application have achieved skin-patchable, fully implantable NEP devices for   on-body, in-body gene therapy, would healing and in vivo modeling.


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